Gabapentin Usage for Alcohol Disorder and Alcohol Withdrawal

Gabapentin for alcohol-withdrawal

Gabapentin (Generic Neurontin ) is used to help control partial seizures (convulsions) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it.

Gabapentin (Generic Neurontin ) is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. It’s also taken for nerve pain. Nerve pain can be caused by different illnesses, including diabetes and shingles, or it can happen after an injury.

Gabapentin (Generic Neurontin ) works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis. Gabapentin is an anticonvulsant.

Occasionally, gabapentin (Generic Neurontin ) is used to prevent migraine headaches. Gabapentin (Neurontin) and pregabalin (Lyrica) are anticonvulsants and nerve pain medicines which have structural similarities to the inhibitory neurotransmitter GABA.

Gabapentin (Generic Neurontin ) is available only with your doctor’s prescription.

Gabapentin (Generic Neurontin ) is available in the following dosage forms:
Capsule
Tablet
Tablet, Extended Release, 24 HR
Solution
Suspension

DOSAGE FORMS AND STRENGTHS of Gabapentin
Capsules
100 mg: white hard gelatin capsules printed with “PD” on the body and300 mg: yellow hard gelatin capsules printed with “PD” on the body and “Neurontin/300 mg” on the cap
400 mg: orange hard gelatin capsules printed with “PD” on the body and “Neurontin/400 mg” on the cap
Tablets
600 mg: white elliptical film-coated scored tablets debossed with “NT” and “16” on one side
Gabapentin 800 mg: white elliptical film-coated scored tablets debossed with “NT” and “26” on one side
Oral solution: 250 mg per 5 mL (50 mg per mL), clear colorless to slightly yellow solution

Gabapentin (Generic Neurontin ) was developed in 1993 and has indications for shingles (‘postherpetic neuralgia’) and partial-onset seizures. It has had a growing popularity in off-label uses for fibromyalgia, pain from a variety of causes, migraine, cocaine withdrawal, anxiety, and insomnia. A related compound, gabapentin encarbil (Horizant), is approved for shingles and restless leg syndrome. Pregabalin was developed in 2004 and is approved for nerve pain from diabetes and spinal cord injuries, fibromyalgia, and adjunctive treatment of partial-onset seizures. Although prescribed off-label for anxiety in the U.S., it is approved for this purpose in the U.K., where it is sometimes called the ‘new Valium’.

Gabapentin Usage for Alcohol disorder and Alcohol withdrawal

Alcohol use disorder, moderate to severe (alternative agent)

Data from randomized, double-blind, placebo-controlled studies support the use of gabapentin in the maintenance of abstinence in patients with alcohol use disorder.

Gabapentin for alcohol-withdrawal
Gabapentin for alcohol-withdrawal

 

Based on the American Psychiatric Association (APA) guidelines for the pharmacological treatment of patients with alcohol use disorder, gabapentin is suggested for patients with alcohol use disorder (moderate to severe) who want to decrease or abstain from use of alcohol and either prefer gabapentin or are unable to tolerate or are unresponsive to naltrexone and acamprosate .

Based on the VA/DoD clinical practice guideline for the management of substance use disorders, gabapentin given for moderate to severe alcohol use disorder is effective and suggested when first-line pharmacotherapy is contraindicated or ineffective.

Alcohol withdrawal, mild (alternative agent)

Data from a randomized, double-blind, active-controlled study support the use of gabapentin in the treatment of alcohol withdrawal.

Based on the VA/DoD clinical practice guideline for the management of substance use disorders, gabapentin given for mild alcohol withdrawal is effective and suggested when the risk of benzodiazepines outweigh the benefits (eg, inadequate monitoring available, abuse liability, contraindication, adverse reaction).