What is Zanaflex Side Effects ?

Tizanidine is a short-acting muscle relaxer that’s marketed under the brand name Zanaflex.

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It’s used to treat muscle spasms caused by certain conditions such as multiple sclerosis, ALS, or spinal cord injury.

It is also prescribed off-label for certain headache disorders, symptoms of fibromyalgia, and as a sleep aid.

Tizanidine works by blocking nerve impulses that are sent to your brain. If you are suffering from spasms, cramping, and tightness of the muscles, your doctor may prescribe tizanidine.

Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Tizanidine Warnings

Tizanidine is a short-acting medication that you should only take for daily activities that require relief from muscle spasms.

Using too much tizanidine can severely damage your liver, causing liver failure.

Tell your doctor if you have any type of previous injury to your liver. Your doctor will likely check blood levels after a month of use if you fall into this category.

It’s also important to inform your doctor if you have experienced kidney failure.

Call your doctor immediately if you develop dry mouth, dizziness, a strong desire for sleep, or any sign of weakness while taking tizanidine. Your dosage may have to be reduced or discontinued.

You should not drive, use heavy machinery, or do any activity that requires you to be alert while using tizanidine.

If you are scheduled for surgery, let your doctor know you are taking tizanidine.

Before having surgery, tell your doctor or dentist about all the products you use, including over-the-counter (OTC) drugs.

In older adults, the effects of tizanidine may also last much longer.

Pregnancy and Tizanidine

Tizanidine may be harmful to an unborn baby.

Animal studies have shown an adverse effect, but there are no adequate studies in pregnant women. Tell your doctor if you are pregnant or might become pregnant during treatment.

Do not use this medication without telling your doctor if you are breastfeeding.

Tizanidine ‘High’ and Recreational Use

Because of tizanidine’s sedative effects, numerous online and anecdotal reports have suggested that some people abuse the drug for a narcotic-like “high.”

However, tizanidine is not a narcotic.

Take tizandine only as directed by your doctor, and keep this and all other drugs away from children, teenagers, and anyone for whom the drug has not been prescribed.

Tizanidine Side Effects

      • Dry mouth
      • Weakness
      • Fatigue
      • Dizziness
      • Nervousness
      • Depression
      • Vomiting
      • Tingling sensation in the arms, legs, hands, and feet
      • Constipation
      • Diarrhea
      • Stomach pain
      • Heartburn
      • Increased muscle spasms
      • Back pain
      • Rash
      • Sweating
      • Light-colored stools

Tell your doctor if any of these symptoms are severe or do not go away.

Serious Side Effects of Tizanidine

Some side effects of tizanidine can be serious.

If you experience any of these symptoms, call your doctor immediately:

      • Nausea
      • Extreme tiredness
      • Unusual bleeding or bruising
      • Lack of energy
      • Loss of appetite
      • Pain in the upper right part of the stomach
      • Yellowing of the skin or eyes (jaundice)
      • Unexplained flu-like symptoms
      • Seeing things or hearing voices that do not exist
      • Slow heartbeat
      • Changes in vision

Let your doctor know if you have any other unusual problems while taking tizanidine.

Tizanidine Interactions

Let your doctor know about all other medicines and supplements you’re taking before taking tizanidine.

Using tizanidine along with the following medicines is not recommended:

      • Acyclovir (Zovirax)
      • Ciprofloxacin (Cipro)
      • Dronedarone (Multaq)
      • Fluvoxamine (Luvox)
      • Pimozide (Orap)
      • Saquinavir (Invirase)
      • Thioridazine (Mellaril)

Food has a complex effect on how tizanidine is absorbed and processed in the body.

Starting at a lower dose and gradually increasing the dose minimizes the risk for adverse effects.

Unless your doctor tells you otherwise, continue your normal diet and take your medicine when you eat.

Alcohol and Tizanidine

Alcohol increases the overall amount of drug in the bloodstream.

You should not drink alcohol while taking Tizanidine.

Tizanidine Dosage

Tizanidine is available in both capsule and tablet form (2 mg and 4 mg tablets).

The medication in the capsule is absorbed differently by the body than the medication in the tablet, so one product cannot be substituted for the other.

When you have your prescription filled, look at the tablets or capsules in the bottle and make sure that you have received the right product.

Tizanidine also reacts differently depending on whether you take it with food or on an empty stomach, or if you sprinkle the contents of the capsule on food.

The usual starting dose is 2 mg taken by mouth every six to eight hours. A maximum of three doses can be taken in a 24-hour period. Your doctor could increase the strength in 2- to 4-mg steps to help reach the optimum effect and tolerance for your condition.

In order to reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose.

Follow your doctor’s instructions carefully.

Tizanidine Withdrawal

Tizanidine may cause you to have withdrawal reactions, especially if it has been used regularly for a long time or in high doses.

Withdrawal symptoms, such as anxiety, tremor, increased blood pressure, heart rate, and muscle tenseness, may occur if you suddenly stop using this medication.

To prevent this from happening, your doctor may reduce your dose gradually to discontinue your use of tizanidine.

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Tizanidine Overdose

Get immediate help or go to an emergency room if you suspect you have taken too much tizanidine.

Symptoms of an overdose include:

      • Blurred vision
      • Chest pain
      • Confusion
      • Difficult or troubled breathing
      • Dizziness, faintness, or lightheadedness when getting up from a lying position
      • Irregular, fast or slow, or shallow breathing
      • Loss of consciousness
      • Pale or blue lips, fingernails, or skin
      • Severe sleepiness
      • Sweating

Tizanidine (Generic Zanaflex) Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Chest pain or discomfort
  2. fever or chills
  3. nausea or vomiting
  4. nervousness
  5. pain or burning while urinating
  6. unusual tiredness

Less common

  1. Blurred vision
  2. flu-like symptoms
  3. irregular heartbeat
  4. itching skin
  5. kidney stones
  6. right upper stomach tenderness
  7. seeing things that are not there
  8. shortness of breath
  9. weight gain

Incidence not known

  1. Continuing vomiting
  2. general feeling of tiredness or weakness
  3. headache
  4. light-colored stools

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Blurred vision
  2. change in consciousness
  3. chest pain or discomfort
  4. confusion
  5. decreased awareness or responsiveness
  6. difficult or troubled breathing
  7. dizziness, faintness or lightheadedness when getting up from a lying position
  8. irregular, fast or slow, or shallow breathing
  9. lightheadedness, dizziness, or fainting
  10. loss of consciousness
  11. pale or blue lips, fingernails, or skin
  12. severe sleepiness
  13. sleepiness or unusual drowsiness
  14. slow or irregular heartbeat
  15. sweating
  16. unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Dizziness or lightheadedness, especially when getting up from a lying or sitting position
  2. drowsiness
  3. dry mouth
  4. fatigue
  5. sleepiness
  6. weakness

Less common

  1. Constipation
  2. nervousness
  3. sore throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Generic Zanaflex is a muscle relaxant prescription, and we do not suggestion for a long time. The best way is to do more exercising to make you more strong. If you can not do regular exercise, you can also take some health foods such as USANA Nutritions and make yourself more beauty by using
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Zanaflex During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant during treatment with Zanaflex; it may harm a fetus. It is unknown if Zanaflex passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Zanaflex may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses.

Our Zanaflex Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

      • a light-headed feeling, like you might pass out;
      • weak or shallow breathing;
      • confusion, hallucinations; or
      • pain or burning when you urinate.

Common side effects may include:

      • drowsiness, dizziness, weakness;
      • feeling nervous;
      • blurred vision;
      • flu-like symptoms;
      • dry mouth, trouble speaking;
      • abnormal liver function tests;
      • runny nose, sore throat;
      • urination problems;
      • vomiting, constipation; or
      • uncontrolled muscle movements.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Important warnings

  • Low blood pressure warning: Tizanidine can cause very low blood pressure that leads to dizziness or fainting. To help reduce this risk, your doctor may prescribe the lowest dose of this drug that works for you. If you already take medications that lower blood pressure, your doctor may check your blood pressure more often.
  • Liver damage warning: Tizanidine can cause liver damage. If you have liver disease, talk with your doctor about whether this drug is safe for you. If you take this drug, your doctor may monitor you for changes in how well your liver works.
  • Hallucinations or delusions warning: Tizanidine can cause visual hallucinations (seeing things that aren’t real). It can also cause delusions (believing things that aren’t real). If have either of these side effects, stop taking this drug and call your doctor right away.

What is tizanidine?

Tizanidine is a prescription drug that comes as an oral tablet and an oral capsule.

Tizanidine oral tablet is available as a brand-name drug Zanaflex. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Why it’s used

Tizanidine oral tablet is used to manage muscle spasms. Symptoms can include muscle tightness, pain, or stiffness. This drug is often used for people with multiple sclerosis, spinal cord injury, or muscle spasticity.

How it works

Tizanidine belongs to a class of drugs called alpha-2-adrenergic agonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Tizanidine reduces the activity of nerves in the spinal cord that control muscles. This helps to reduce muscle spasms.

Tizanidine side effects

Tizanidine oral tablet may cause drowsiness. It may also cause other side effects.

More common side effects

The more common side effects of tizanidine can include:

  • dry mouth
  • tiredness
  • weakness
  • dizziness
  • urinary tract infection
  • constipation
  • vomiting
  • trouble speaking
  • runny nose
  • sore throat
  • vision problems

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Hallucinations. Symptoms can include:
    • seeing things that aren’t real
  • Delusions. Symptoms can include:
    • believing things that aren’t real
  • Extremely low blood pressure. Symptoms can include:
    • dizziness or lightheadedness, especially when standing after sitting or lying down
  • Liver damage. Symptoms can include:
    • increased bleeding or bruising
    • yellowing of your skin or the whites of your eyes

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Tizanidine may interact with other medications

Tizanidine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with tizanidine are listed below.

Drugs that should not be used with tizanidine

Do not take these drugs with tizanidine. When used with tizanidine, these drugs can cause dangerous effects in the body. Examples of these drugs include:

  • Fluvoxamine and ciprofloxacin (Cipro). Using these drugs with tizanidine may cause very low blood pressure. It may also cause increased drowsiness or decreased muscle control.
  • Other alpha-2 agonist medications such as clonidine, methyldopa, guanfacine, or guanabenz. Using these drugs with tizanidine can cause very low blood pressure.

Drugs that increase the risk of side effects from tizanidine

Taking tizanidine with certain medications raises your risk of side effects from tizanidine. This is because the amount of tizanidine in your body is increased. Avoid using these drugs with tizanidine if possible. Examples of these drugs include:

  • Zileuton. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.
  • Certain antibiotics called fluoroquinolones (other than ciprofloxacin), such as levofloxacin, moxifloxacin, or gemifloxacin. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.
  • Certain heart rhythm drugs such as amiodarone, mexiletine, propafenone, or verapamil. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.
  • Antacids such as cimetidine or famotidine. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.
  • Oral contraceptives. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.
  • Acyclovir. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.
  • Ticlopidine. Increased side effects can include decreased blood pressure, decreased heart rate, or extreme drowsiness.

Using tizanidine with the following drugs can cause excessive sedation (drowsiness):

  • Benzodiazepines such as alprazolam, lorazepam, or diazepam.
  • Opioids such as morphine, methadone, or oxycodone.
  • Certain antidepressants such as amitriptyline, nortriptyline, or protriptyline.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.